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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: NEDD4L All Species: 26.67
Human Site: S336 Identified Species: 48.89
UniProt: Q96PU5 Number Species: 12
    Phosphosite Substitution
    Charge Score: -0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q96PU5 NP_001138436.1 975 111932 S336 L I Q R E P S S R L R S C S V
Chimpanzee Pan troglodytes XP_001140254 911 104904 S336 L I Q R E P S S R L R S C S V
Rhesus Macaque Macaca mulatta XP_001088661 1010 115306 S371 L V Q R E P S S R L R S C S V
Dog Lupus familis XP_533393 1027 117927 S388 L M Q R E P S S R L R S C S V
Cat Felis silvestris
Mouse Mus musculus Q8CFI0 1004 115400 S365 L I Q R E P S S R L R S C S V
Rat Rattus norvegicus Q62940 887 102376 T330 I V R E D E N T I Y S G Q A V
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001511197 1255 141275 A496 S Q L H I Q F A R G N E G K V
Chicken Gallus gallus XP_424462 1045 119140 S406 L I Q R D P S S R L R S C S V
Frog Xenopus laevis Q2TAS2 751 86306 G214 D E N T P I T G T N G A S C G
Zebra Danio Brachydanio rerio A9JRZ0 765 87445 V228 V P A D D P R V Q E R R V R S
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9VVI3 1007 114856 S375 D P T V D H T S F V Y N S L R
Honey Bee Apis mellifera XP_395191 782 90150 R244 A A T E F Q R R F H I S A D D
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P39940 809 91798 Q272 T E A E R G N Q L N A N T E L
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 93.4 92.4 90.8 N.A. 94.3 48 N.A. 43.9 85.6 34.1 34.3 N.A. 47.2 49.4 N.A. N.A.
Protein Similarity: 100 93.4 93.7 92.2 N.A. 95.6 60 N.A. 54 88.4 49 49.5 N.A. 61.8 61.1 N.A. N.A.
P-Site Identity: 100 100 93.3 93.3 N.A. 100 6.6 N.A. 13.3 93.3 0 13.3 N.A. 6.6 6.6 N.A. N.A.
P-Site Similarity: 100 100 100 100 N.A. 100 53.3 N.A. 20 100 13.3 33.3 N.A. 33.3 6.6 N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. 37 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 52.9 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 0 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 20 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 8 8 16 0 0 0 0 8 0 0 8 8 8 8 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 47 8 0 % C
% Asp: 16 0 0 8 31 0 0 0 0 0 0 0 0 8 8 % D
% Glu: 0 16 0 24 39 8 0 0 0 8 0 8 0 8 0 % E
% Phe: 0 0 0 0 8 0 8 0 16 0 0 0 0 0 0 % F
% Gly: 0 0 0 0 0 8 0 8 0 8 8 8 8 0 8 % G
% His: 0 0 0 8 0 8 0 0 0 8 0 0 0 0 0 % H
% Ile: 8 31 0 0 8 8 0 0 8 0 8 0 0 0 0 % I
% Lys: 0 0 0 0 0 0 0 0 0 0 0 0 0 8 0 % K
% Leu: 47 0 8 0 0 0 0 0 8 47 0 0 0 8 8 % L
% Met: 0 8 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 8 0 0 0 16 0 0 16 8 16 0 0 0 % N
% Pro: 0 16 0 0 8 54 0 0 0 0 0 0 0 0 0 % P
% Gln: 0 8 47 0 0 16 0 8 8 0 0 0 8 0 0 % Q
% Arg: 0 0 8 47 8 0 16 8 54 0 54 8 0 8 8 % R
% Ser: 8 0 0 0 0 0 47 54 0 0 8 54 16 47 8 % S
% Thr: 8 0 16 8 0 0 16 8 8 0 0 0 8 0 0 % T
% Val: 8 16 0 8 0 0 0 8 0 8 0 0 8 0 62 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 8 8 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _